Alterations in the expression of IGF‑I isoforms and binding proteins during the wound healing process

There is increasing evidence to indicate that insulin‑like growth factor (IGF)‑1 plays a crucial role in the regeneration of different tissues following injury. Notably, despite escalating number animal studies, studies investigating IGF‑1 wound healing process humans are fewer. In this context, aim present study was evaluate variations expression isoforms (IGF1‑Ea, IGF1‑Eb and IGF1‑Ec), as well its binding protein receptor (IGF‑BP3 IGF‑1R) during patients. The population comprised 21 patients presenting with first episode sacrococcygeal pilonidal disease. Samples were obtained surgery, on days 2, 7 14 post‑operatively. levels isoforms, evaluated using reverse transcription‑quantitative PCR. Statistical analyses performed GraphPad Prism software. Kruskal‑Wallis test Dunn's post hoc utilized. results revealed statistically significant difference IGF‑BP3 IGF‑1R (P=0.014 P=0.018, respectively). Specifically, pairwise post‑hoc Dunn indicated significantly decreased 2nd post‑operative day compared while increased at remaining not altered healing. On whole, demonstrated herein, appear play process, particularly large open wounds disease treatment. Further warranted exact role, possible use these proteins enhancers